<i>Auricularia heimuer</i> Ameliorates Oxidative Stress and Inflammation to Inhibit Atherosclerosis Development in ApoE^-/- Mice.

ABSTRACT: Background: Atherosclerosis is a chronic vascular disease triggered by lipid accumulation. Auricularia heimuer is rich in various bioactive compounds that have anti-inflammatory, antioxidant, and hypolipidemic properties. The specific beneficial effects of A. heimuer on atherosclerosis and its underlying mechanisms require further investigation. Methods: In this study, ApoE^-/- mice were utilized as models of atherosclerosis induced by a high-fat diet (HFD) to investigate the effects of A. heimuer. Analyses of gut microbiota and serum metabolomics were conducted to elucidate the potential mechanism. Results: In HFD-fed ApoE^-/- mice, A. heimuer significantly inhibited the increase in body weight, regulated lipid levels, a

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12430062 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature