Systemic Inflammation Indices, Chemokines, and Metabolic Markers in Perimenopausal Women.

ABSTRACT: Background: Menopause and metabolic syndrome (MetS) are linked to chronic low-grade inflammation. However, the role of chemokines and systemic inflammatory indices such as the systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) in perimenopausal women remains poorly understood. Methods: This cross-sectional study evaluated inflammatory markers, chemokines, and systemic indices in perimenopausal women recruited in Poland. Sociodemographic and health-related information was obtained using a custom questionnaire, along with anthropometric measurements and laboratory analyses. Results: A total of 230 women aged 44-65 years were included. Women with BMI ≥ 25 kg/m² had significantly higher IL-6 (median 4.9 vs. 2.3 pg/mL, p</

SUBMITTER: Cybulska AM 

PROVIDER: S-EPMC12430069 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature