GABAergic and α-Glucosidase-Inhibitory Potentials of Fractions and Isolated Xanthones from <i>Hypericum revolutum</i> Vahl subsp. <i>revolutum</i>.

ABSTRACT: This study aimed to investigate the glycaemic control potential and modulation of GABA-induced chloride currents (I_GABA) of H. revolutum and the possible bioactive xanthones. Fractions from the leaf and stem extracts (dichloromethane and methanol) were assessed for in vitro α-glucosidase-inhibitory potential and their ability to modulate I_GABA (GABAergic effect) through GABA_A receptors heterologously expressed in Xenopus oocytes. Xanthones 4-hydroxy-2,3-dimethoxy-9H-xanthen-9-one (1), 3-hydroxy-2,4-dimethoxy-9H-xanthen-9-one (2) and trans-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-2,3-dihydro-7H-[1,4]dioxino[2,3-c]xanthen-7-one (3) were isolated from the stem and tested in the GAB

SUBMITTER: Chukwuma MS 

PROVIDER: S-EPMC12430133 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature