Thermal Decomposition and Prebiotic Formation of Adenosine Phosphates in Simulated Early-Earth Evaporative Settings.

ABSTRACT: Adenosine nucleotides and polyphosphates play a significant role in biochemistry, from participating in the formation of genetic material to serving as metabolic energy currency. In this study, we examine the stability and decomposition rates of adenosine phosphates-5'-AMP, 5'-ADP, and 5'-ATP (mentioned simply as AMP, ADP and ATP hereafter)-at temperatures of 22-25 °C, 50-55 °C, 70-75 °C, and 85-90 °C, at a pH of 4, over periods of 2 and 4 days, in both saltwater and ultrapure water, under unsealed and completely dried down conditions. We found that adenosine phosphates degrade rapidly under heat and dehydration, particularly at temperatures above 25 °C. Among the three compounds, AMP is the most stable, maintaining its integrity between 22 and 55 °C, whereas ATP begins to degrade at 22-25

SUBMITTER: Gull M 

PROVIDER: S-EPMC12430388 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature