Synthesis, Structure, DNA/BSA Binding, DNA Cleaving, Cytotoxic and SOD Mimetic Activities of Copper(II) Complexes Derived from Methoxybenzylamine Schiff Base Ligands.

ABSTRACT: Schiff base ligands prepared from salicylaldehyde and 2-, 3- and 4-methoxybenzylamine were used to prepare copper(II) complexes, characterized by spectral methods, elemental analysis and X-ray crystallography in the case of complex 4a derived from 2-methoxybenzylamine. The DNA cleavage activity of the prepared complexes was exceptional, with best activities of over 95% one-strand cleavage for 4c at 3 mM and full double-strand cleavage for complex 4a at 5 mM. Absorption titration studies with ct-DNA revealed good binding constants (at 10⁵ M^-1) with a decrease of up to 56% light absorption. Meanwhile, the EB-DNA displacement method and viscosity studies revealed groove binding as a possible binding mode. For BSA binding studies, all three complexes

SUBMITTER: Lintnerova L 

PROVIDER: S-EPMC12430429 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature