From Mushrooms to Molecules: Exploring Depsidones in <i>Ganoderma lucidum</i> for Antioxidant and Anticancer Applications.

ABSTRACT: Fungi are a prolific source of diverse bioactive metabolites, yet many remain unexplored. Among these, depsidones are a rare class of compounds with significant biological potential, but they are seldom reported in mushrooms. This study investigated the medicinal fungus Ganoderma lucidum, known for its extensive therapeutic use in traditional medicine. Fruiting bodies were extracted using petroleum ether, ethyl acetate, n-butanol, and methanol. Extracts were screened phytochemically and assessed for total phenolic content and antioxidant activity using the DPPH assay. Ethyl acetate extract exhibited the highest phenolic yield and antioxidant potential and was subsequently evaluated for cytotoxicity against HepG2, HCT116, MCF7, and A549 cancer cell lines. It showed notable anticancer

SUBMITTER: Mohamed SHA 

PROVIDER: S-EPMC12430494 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature