Albumin-Coated Copper Oxide Nanoparticles for Radiosensitization of Human Glioblastoma Cells Under Clinically Relevant X-Ray Irradiation.

ABSTRACT: Glioblastoma (GBM) is the most aggressive and treatment-resistant primary brain tumor in adults. Despite current multimodal therapies, including surgery, radiation, and temozolomide chemotherapy, patient outcomes remain poor. Enhancing tumor radiosensitivity through biocompatible nanomaterials could provide a promising integrative strategy for improving therapeutic effectiveness. This study aims to evaluate the potential of bovine serum albumin-coated copper oxide nanoparticles (BSA@CuO-NPs) to enhance radiosensitivity in U87-MG cells under clinically relevant X-ray irradiation. In brief, BSA@CuO-NPs were synthesized via carbodiimide crosslinking and characterized by DLS, SEM, and zeta potential analysis. U87-MG cells were treated with BSA@CuO-NPs alone or in combination with X-ray irradia

SUBMITTER: Suwannasing C 

PROVIDER: S-EPMC12430620 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature