Targeting Lymphedema in Overweight Breast Cancer Survivors: A Pilot Randomized Controlled Trial of Diet and Exercise Intervention.

ABSTRACT: Background/Objectives: Breast cancer-related lymphedema (BCRL) is more prevalent and severe in women with overweight or obesity. This study evaluated the effect of a comprehensive lifestyle intervention-comprising supervised exercise, a hypocaloric Mediterranean diet, and optional meal replacement-on lymphedema outcomes in this population. Methods: In this pilot randomized controlled trial, 112 women with BCRL and BMI 25-40 kg/m² were assigned to an intervention group-receiving supervised resistance and aerobic training, dietary counseling, and optional high-protein meal replacement-or to a control group with standard advice. The primary outcome was change in affected limb volume at 3 and 6 months. Secondary outcomes included morphofunctional parameters, muscle str

SUBMITTER: Ruiz-Molina Y 

PROVIDER: S-EPMC12430713 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature