Temporal effects of sympathetic denervation on aortic remodeling and rupture in experimental abdominal aortic aneurysm.

ABSTRACT: Abdominal aortic aneurysm (AAA) is a life-threatening condition with no effective pharmacologic therapies, and increasing evidence suggests that the sympathetic nervous system (SNS) contributes to disease progression. However, the temporal effects of SNS modulation on AAA stability remain unclear. To investigate the impact of SNS modulation on aneurysm outcomes, we induced AAAs in male ApoE^-/- mice via continuous subcutaneous infusion of angiotensin II. Using three-dimensional light sheet microscopy, we found that ruptured AAAs exhibited the highest sympathetic innervation in experimental aneurysms. Sympathetic denervation was performed using intraperitoneal 6-hydroxydopamine, administered either serially (before and during AAA induction) or at a delayed time point (after

SUBMITTER: Chao CL 

PROVIDER: S-EPMC12430726 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature