Interactive and Joint Effects of Obesity and Insulin Resistance on Hypertension in Adolescents and the Mediating Role of Insulin Resistance-Five Provinces, China.

ABSTRACT: Background: The global prevalence of pediatric hypertension is on the rise. Adolescence is a period of high prevalence of childhood hypertension. Obesity and insulin resistance (IR) are important risk factors in the development of hypertension, but their interaction and combined effects on adolescent hypertension remain unclear. Methods: This cross-sectional study utilized data from the China National Nutrition and Health Surveillance of Children and Lactating Mothers (2016-2017). A total of 7031 adolescents aged 12-17 years from five provinces were included. The triglyceride-glucose index (TyG) was used as an indicator of IR. Multivariable logistic regression and generalized linear mixed-effect models were used to assess the interaction and joint effects of IR and obesity (m

SUBMITTER: Zhu H 

PROVIDER: S-EPMC12430777 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature