Association between lactate-to-albumin ratio and 28-day ICU mortality in pediatric severe pneumonia patients.

ABSTRACT:

Introduction

The lactate-to-albumin ratio (LAR) has emerged as a promising prognostic biomarker in critical care, reflecting both metabolic dysfunction and inflammatory status. However, its prognostic value in pediatric severe pneumonia remains underexplored. This study aimed to investigate the association between LAR and 28-day ICU mortality in pediatric severe pneumonia patients using data from the Paediatric Intensive Care database.

Methods

A retrospective cohort study was conducted involving 617 pediatric severe pneumonia patients admitted to the ICU between 2010 and 2018. LAR was calculated as the ratio of lactate (mmol/L) to albumin (g/dL). The primary outcome was 28-day ICU mortality. Cox proportional hazards regression models were used to assess the relationship betw

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12431254 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature