Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment.

ABSTRACT: Endometriosis is characterized by the presence of endometrial tissue outside the uterine cavity. The administration of drugs designated for this condition has significant adverse effects, such as signs of estrogen insufficiency and suppression of ovulation. Considering this issue, this study aims to employ drugs repurposing approaches for the treatment of endometriosis. The GSE120103 dataset was selected to assess the expression of genes involved in endometriosis, then differentially expressed genes (DEGs) were identified using the "Limma" package in R Studio. Functional and pathway enrichment analysis of 708 up-regulated and 414 down-regulated DEGs was performed using ShinyGO 0.81 and DAVID tools. the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) was then used to bu

SUBMITTER: Sanami S 

PROVIDER: S-EPMC12431326 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature