Photopolymerization 3D-Printed Dual-Modal Flexible Sensor for Glucose and pH Monitoring.

ABSTRACT: Currently, flexible sensors based on electrochemical principles are predominantly limited to single-parameter detection, making it challenging to meet the demand for synchronous monitoring of multiple analytes in complex physiological environments. This study presents a 3D-printed flexible sensor for synchronous glucose/pH detection. Glucose was quantified via H₂O₂ oxidation current (GOD-catalyzed reaction), while pH was measured through polyaniline (PANI) resistance changes. The ionogel-based microneedle electrode ensures mechanical robustness. At 0.2 V, optimal signal decoupling was achieved: glucose oxidation current dominates, while PANI's polarization effect is minimized. Neutral pH minimally affected glucose oxidase (GOD) activity, and low glucose concentrations

SUBMITTER: Lin S 

PROVIDER: S-EPMC12431340 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature