Interfacial Dynamics in the Fabrication of Various Concave Hydrogel Discs for Enhanced Biosensing.

ABSTRACT: Hydrogel-based biosensors are commonly used in diagnostic applications. However, their performance remains constrained by slow analyte diffusion within polymer matrices, particularly when larger biomolecules are involved. Concave hydrogel geometries present a promising solution to enhance diffusion rates through increased surface area. However, the interfacial dynamics governing their formation must be studied. In this research, we investigated the interfacial dynamics that influence the formation of concave hydrogel discs fabricated by a simple pipetting method. We characterized the fluid interactions occurring during droplet deposition of alginate and CaCl₂ solutions. A three-phase flow model incorporating confocal microscopy validation was employed to simulate time-dependent

SUBMITTER: Bakhshayesh AG 

PROVIDER: S-EPMC12431547 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature