Myostatin antisense administration prevents sepsis-induced muscle atrophy and weakness in male mice.

ABSTRACT: Muscle atrophy and weakness are serious problems associated with sepsis. However, only a few pharmacological interventions are available to date. In this study, myostatin antisense was used to prevent sepsis-induced muscle atrophy and weakness. Sepsis was induced in 8-week-old male C57BL/6J mice via intraperitoneal injection of 1 mg/g cecal slurry (CS). Myostatin antisense was injected into the right tibialis anterior muscle. Myostatin mRNA was measured in the tibialis anterior and quadriceps femoris muscles on Day 1. The body weight, grip strength, and cross-sectional area of the tibialis anterior muscle were measured on Day 6. The administration of myostatin antisense decreased myostatin expression on Day 1 in the injected side (0.023 ± 0.010 in CS vs. 0.008 ± 0.002 in CS + antisense) as

SUBMITTER: Nakanishi N 

PROVIDER: S-EPMC12431578 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature