Increased contractility affects left ventricular kinetic energy in pulmonary hypertension.

ABSTRACT: Precapillary pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance (PVR), with progressively altered right (RV) and left ventricular (LV) hemodynamics and function. Kinetic energy (KE) from 4D flow cardiovascular magnetic resonance (CMR) is a measure of intracardiac hemodynamics. In this observational case-control study, we investigate physiological mechanisms influencing RV-KE and LV-KE in PH. Twenty PH patients and 12 healthy controls underwent CMR including cine images and 4D flow. LV contractility was derived from noninvasive pressure-volume loops, and PVR from right heart catheterization. RV-KE and LV-KE were computed for systole, early and late diastolic filling, and indexed to stroke volume (SV). Systolic RV-KE did not differ between patients and co

SUBMITTER: Bergstrom E 

PROVIDER: S-EPMC12431581 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature