The contribution of the brain-gut-microbiome axis to intergenerational abnormalities in a rat model of perioperative neurocognitive disorder.

ABSTRACT:

Background

The brain-gut-microbiome (BGM) axis is a communication network through which the brain and gastrointestinal microbiota interact via neural, hormonal, immune, and gene expression mechanisms. Gut microbiota dysbiosis is thought to contribute to neurocognitive disorders, including perioperative neurocognitive disorder (PND), and to various metabolic abnormalities. Recently, we reported that sevoflurane induces neurocognitive deficits in exposed rats as well as their future offspring, with male offspring being particularly affected (intergenerational PND). In this study, we examined in the same animals whether the intergenerational effects of sevoflurane involve abnormalities in the BGM axis, and whether they are mitigated by paternal pretreatment with either the Na+-K+-Cl-

SUBMITTER: Khan ZA 

PROVIDER: S-EPMC12431638 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature