Aging Effects on Lipid Metabolism in Response to Traumatic Brain Injury.

ABSTRACT: Traumatic brain injury (TBI) is highly prevalent among very young and older adults, with poorer outcomes and longer recovery in aged individuals. The brain is a lipid-rich organ and high rates of membrane remodeling occur during recovery, yet remain poorly delineated, especially in aged. To determine the impact of age on lipid metabolism during TBI recovery, TBI was induced by control cortical impact in 3 (young) and 20 (aged) month-old mice. The ipsilateral cortex was harvested at 1-, 3-, 7-, and 28-day post injury (dpi) for analysis of gene expression, membrane lipidomics, total lipid fatty acid profile, and intermediates of fatty acid β-oxidation, acylcarnitines. Lipid metabolizing genes were largely downregulated in response to TBI in young mice, yet remained unchanged or were increase

SUBMITTER: Fernandez RF 

PROVIDER: S-EPMC12431718 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature