Causal relationships between gut microbiota and depression/anxiety disorders: A 2-sample Mendelian randomization study.

ABSTRACT: Evidence shows that the composition of the gut microbiota (GM) is associated with depression and anxiety disorders. However, the causal relationship between them remains controversial. To investigate the potential causal relationship between the GM and depression/anxiety disorders and to identify specific bacterial taxa, we conducted a 2-sample Mendelian randomization (MR) analysis on the gut microbiome implicated in depression and anxiety disorders. We incorporated summary data from genome-wide association studies (GWAS) of the microbiome derived from 7738 individuals in the Dutch Microbiome Project and 18,340 individuals in the MiBioGen consortium as our exposure variable. Concurrently, the GWAS of depression and anxiety disorders was employed as our outcome variable. The principal estim

SUBMITTER: Fan T 

PROVIDER: S-EPMC12431749 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature