Prognostic significance of in patients with chronic lymphocytic leukemia: A meta-analysis.

ABSTRACT: NOTCH1 and SF3B1 mutations are common in CLL, but their prognostic value for overall survival (OS) and progression-free survival (PFS), as well as time to first treatment (TTFT) and treatment-free survival (TFS), remains uncertain. This meta-analysis systematically evaluates their impact. A systematic search of PubMed, Embase, Cochrane Library, and Web of Science was performed up to March 2025. Relevant study data and prognostic outcomes were extracted, and pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using fixed- or random-effects models based on heterogeneity. A total of 38 studies with 24,060 CLL patients met the criteria. Among them, 32 and 23 studies evaluated the prognostic impact of NOTCH1 and SF3B1 mutations, respectively. Compared to wild-type, NO

SUBMITTER: Huang L 

PROVIDER: S-EPMC12431906 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature