Validation of clinicopathologic features of a genetic myelodysplastic syndrome classification in an independent cohort.

ABSTRACT:

Background

Current classification systems for myelodysplastic syndromes (MDS) incorporate morphologic findings, blast percentage, and some genetic features such as del(5q) and SF3B1 and TP53 mutations. A recent comprehensive molecular taxonomy proposed by the MDS-International Working Group (MDS-IWG) categorizes MDS into 16 molecular groups and two residual groups and describes associations with various clinicopathological features and differing overall survival among groups.

Purpose

In this study, we attempt to validate the findings described in the MDS-IWG classification in an independent cohort.

Methods

We applied the MDS-IWG classification to 484 cases of MDS and myelodysplastic-type chronic myelomonocytic leukemia.

Results

We verified numerous findings and

SUBMITTER: Patwardhan PP 

PROVIDER: S-EPMC12431936 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature