Clinical characteristics and outcome of pediatric patients with high-risk acute promyelocytic leukemia, with special focus on risk factors of early death.

ABSTRACT: To evaluate the real-life outcome of pediatric high-risk acute promyelocytic leukemia (APL) after up-front treatment with all-trans retinoic acid (ATRA) and arsenic trioxide. Thirty-two pediatric patients diagnosed with high-risk APL from 2015 to 2022 were retrospectively studied. Of the 326 children with acute myeloid leukemia, 86 (26.4%) were diagnosed with APL. Thirty-two patients (37.2%) were designated to the high-risk group at diagnosis. Seven patients (21.8%) died during induction chemotherapy and the other 25 patients all achieved molecular complete remission (MCR) after induction chemotherapy. The underlying causes of early death (ED) were identified as follows: six cases of intracranial hemorrhage, and one case of pneumorrhagia accompanied by differentiation syndrome. Six ED case

SUBMITTER: Gao Q 

PROVIDER: S-EPMC12432044 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature