Investigating the controversy surrounding statin therapy and Achilles tendinopathy using Mendelian randomization analysis.

ABSTRACT:

Background

The relationship between statin therapy and tendon injuries, particularly Achilles tendinopathy, which is the body's largest and strongest tendon, remains controversial.

Aim

This study employed Mendelian Randomization (MR) analysis to explore the causal link between statin therapy and Achilles tendinopathy (ATP).

Method

Summary statistics were obtained from genome-wide association studies on statin medication and four specific statin drugs from public databases, as well as data related to two ATP phenotypes, namely Achilles tendinitis and Achilles tendon injury. Furthermore, a two-sample bidirectional MR analysis was conducted to investigate the association between statin therapy and ATP. The primary method used was the inverse variance weighted (IVW) metho

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12432074 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature