Glycoprotein non-metastatic melanoma protein B is a potential biomarker for arthroplasty aseptic loosening.

ABSTRACT: Endoprosthesis loosening is the major cause of arthroplasty failure. Currently, radiography, histo-pathological classification of the periprosthetic membrane, and microbiological examination are used retrospectively for diagnosis. Prospective options for early diagnosis are not available. The study presented here aimed to identify (prospective) molecular biomarkers of implant loosening in tissue samples from patients. Four patient cohorts (primary and revision arthroplasty due to aseptic loosening of hip or knee) were defined. Aseptic loosening of implants was assessed by the standardised approach of the Knee Society Total Knee Arthroplasty Roentgenographic Evaluation and Scoring System. Synovial fluid, bone marrow, and blood were collected from 96 patients. Mesenchymal stromal cells (BM-M

SUBMITTER: Schadzek P 

PROVIDER: S-EPMC12432123 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature