Age, muscle, and gender specific characterization of muscle degeneration in a mouse model of calpainopathy.

ABSTRACT: Establishing well-described mouse models of hereditary diseases is increasingly important for testing new therapeutic approaches, such as gene replacement therapy. In particular, a detailed description of muscle pathology, especially at early timepoints of the disease, is crucial for determining the optimal timepoint for drug delivery and evaluation of therapeutic success. In this study, we aimed to characterize and quantify the muscle pathology and myofibre morphology of different muscles in a new mouse model for calpainopathy as an example of the heterogenous group of limb girdle muscular dystrophies compared to wildtype controls during the disease. We analysed motor function and muscle tissue of wildtype and Capn3-transgenic mice per gender from 1.5 to 15 months of age. While transgenic

SUBMITTER: Sudkamp N 

PROVIDER: S-EPMC12432131 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature