Increased frontal functional connectivity correlates with structural disconnection in the anterior corpus callosum in healthy older adults.

ABSTRACT: Cognitive aging is a heterogeneous process characterized by a varied decline in brain performance. While the neurophysiological basis of this decline remains poorly understood, age-related alterations in structural connectivity (SC) and functional connectivity (FC) have been implicated. Understanding the relationship between these changes is crucial for identifying early markers of cognitive impairment. In our previous work, we observed that in healthy older adults, diminished performance in a tactile recognition task was associated with reduced fractional anisotropy (FA) in the anterior corpus callosum (aCC). The aim of this study was to investigate the impact of this age-related SC degeneration on the FC between the connected regions. In the current analysis, we examined resting-state fu

SUBMITTER: Braaß H 

PROVIDER: S-EPMC12432219 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature