Glutamine Metabolism and Metabolic Profiling Using 7 T CRT-FID MRSI in Focal Epilepsy.

ABSTRACT:

Background

Approximately one-third of people with epilepsy (PWE) remain drug-resistant. In these cases, surgical resection of the epileptogenic zone may significantly reduce or eliminate seizures. Surgery necessitates precise delineation of the epileptogenic zone (EZ) which proves especially challenging in the 20% of PWE that remain MRI-negative. The purpose of this study was to analyze the feasibility and robustness of ultra-high-field MRSI in identifying and characterizing pathologies in focal epilepsy. In addition, the relationship of glutamate and glutamine was evaluated in the EZ.

Methods

Fifty-six people with focal epilepsy were prospectively measured using 7 T concentric ring trajectory direct acquisition of free-induction-decay MRSI, which generated whole-brain metab

SUBMITTER: Chambers S 

PROVIDER: S-EPMC12432270 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature