Kappa free light chain index predicts long-term disease activity and disability accrual in multiple sclerosis.

ABSTRACT:

Background

The prognostic value of κ-free light chain (κ-FLC) index over the long term is unknown.

Objectives

The objective of the study was to determine whether κ-FLC index determined at disease onset predicts relapse activity and disability accrual during long-term follow-up.

Methods

Patients with a first demyelinating event of the central nervous system who had cerebrospinal fluid and serum sampling were eligible for inclusion. At baseline, demographics, clinical data, number of T2 hyperintense (T2L) and contrast-enhancing lesions (CEL) on MRI were assessed. During follow-up occurrence of relapses, Expanded Disability Status Scale (EDSS) scores and disease-modifying treatments (DMT) were registered. κ-FLC was measured by nephelometry and κ-FLC index calculated as (

SUBMITTER: Berek K 

PROVIDER: S-EPMC12432279 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature