Inter-Hospital Spread of Fluconazole-Resistant C. parapsilosis in Northern Italy: Insights Into Clonal Distribution, Resistance Mechanisms and Biofilm Production.

ABSTRACT:

Background

Starting from 2018 onwards, several outbreaks of fluconazole-resistant C. parapsilosis have been reported in many countries worldwide.

Objectives

Here we report a retrospective study on C. parapsilosis blood isolates collected over 7 years (2018-2024) in two hospitals in Northern Italy.

Patients/methods

The study involved 169 C. parapsilosis isolates collected from individual hospitalised patients. We assessed the antifungal susceptibility of the isolates, evaluated the presence of mutations in the ERG11 gene and performed multilocus microsatellite typing to highlight the genetic relatedness of the strains. All isolates were also tested for their ability to produce biofilm.

Results

Among the 169 clinical isolates, 124 (73.4%) were classified as fluco

SUBMITTER: Palladini G 

PROVIDER: S-EPMC12432348 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature