Identification of immune signatures associated with both SARS-CoV-2 infection and lung transplantation.

ABSTRACT: Lung transplantation (lung-tx) offers the last life-saving option for patients with COVID-19-associated lung injury (CALI). We show that the RBD-specific antibodies are dramatically reduced in these CALI lung-tx patients despite a comparable frequency of CD19⁺ B cells in circulating blood between CALI lung-tx patients and sero-negative controls. In contrast, non-transplant COVID-19 groups maintain a high level of RBD-specific antibodies. Single-cell RNA sequencing of white blood cells (WBCs) reveals three populations expanded in CALI lung-tx patients, including "lung-tx CD14⁺FCGR3B(CD16b)⁺ neutrophils," "lung-tx CD8⁺ T cells," and "KLF2⁺ CD4⁺ T cells," alongside reduced conventional T and B lymphocytes. Elevated expression o

SUBMITTER: Hoffmann AD 

PROVIDER: S-EPMC12432355 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature