Oscillometry-defined Small Airway Dysfunction in Tobacco-exposed Adults with Impaired or Preserved Airflow.

ABSTRACT: Rationale: Small airway dysfunction (SAD) is a key feature of chronic obstructive pulmonary disease and might present in tobacco-exposed adults with normal spirometry. So far, the role of oscillometry-defined SAD in this population is largely unexplored. Objective: To investigate the prevalence of oscillometry-defined SAD and its associations with airway structural changes, quality of life (QoL), metabolic disease, and cardiovascular disease (CVD) in tobacco-exposed adults with impaired airflow or preserved airflow (PA). Methods: In a subcohort (n = 1,628) nested within a lung cancer screening trial, we assessed airway disease using pre-bronchodilator spirometry, oscillometry, and artificial intelligence-powered computed tomography. Impaired airflow included air

SUBMITTER: Abdo M 

PROVIDER: S-EPMC12432392 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature