Rational design of a covalent ACE2 decoy receptor that broadly neutralizes SARS-CoV-2 variants.

ABSTRACT: The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of variants that evade existing vaccines and antibody therapies necessitate novel, potent, and broad-spectrum antiviral strategies. Enhancing therapeutic proteins with additional covalent binding capabilities, such as minibinders and nanobodies, reportedly potentiates their antiviral efficacy by irreversibly capturing the viral cell-entry protein. However, viral mutations that interfere with covalent bonding or reduce viral affinity with therapeutic proteins might compromise the efficacy of this strategy. Therefore, in this study, we aimed to develop a broadly neutralizing covalent angiotensin-converting enzyme 2-Fc (ACE2-Fc) decoy using a rational design strategy that integrates functio

SUBMITTER: Hino N 

PROVIDER: S-EPMC12432405 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature