Update Prognostic Potency of Vascular Endothelial Growth Factor-A in the Acute Lymphoblastic Leukemia Landscape: A Meta-Analysis.

ABSTRACT:

Background

Vascular endothelial growth factor-A (VEGF-A), In combination with other pro-angiogenic factors, plays a pivotal role in angiogenesis and the pathogenesis of acute lymphoblastic leukemia (ALL).

Aims

This meta-analysis aims to evaluate the diagnostic value of VEGF-A and its prognostic relevance in the outcome of patients with ALL.

Methods and results

A comprehensive literature search was conducted up to January 2025 across multiple databases. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were pooled using a random-effects model to quantify effect sizes. Subgroup analyses and meta-regression were employed to explore heterogeneity sources. Data extracted from 15 studies encompassing 674 patients with ALL demonstrated a significant co

SUBMITTER: Aghaei M 

PROVIDER: S-EPMC12432426 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature