Evidence for vitellogenin DNA-binding in honey bees.

ABSTRACT: DNA-binding proteins play essential roles in DNA replication, DNA repair, DNA organization, and several aspects of gene regulation. Their well-studied structures and charge configurations aid in identifying similar functions in other proteins. Vitellogenin (Vg) is a highly conserved protein that is central to egg-yolk formation in most animal taxa. The protein is largely viewed as a transporter, but effects on immunity and behavior are documented. Experiments in honey bees (Apis mellifera) additionally suggest a role in gene regulation. The possibility of Vg-DNA binding has broad relevance due to Vg being phylogenetically widespread and having descendant proteins relevant to human cardiovascular health. Previously, we found that a Vg subunit can translocate to the honey bee nucleus and int

SUBMITTER: Harwood G 

PROVIDER: S-EPMC12432429 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature