Trial Analysis and Interpretation in Critical Care Using the Evidential (Likelihood) Approach: Rationale and Practical Considerations.

ABSTRACT: Selecting the optimal methodological framework for evidence synthesis presents a fundamental challenge in contemporary clinical research. In critical care, in which many interventions yield inconclusive results under traditional P value-based analyses, complementary analytical approaches can enhance our understanding of trial data. Although frequentist statistics remain predominant and Bayesian methods have recently experienced a resurgence of interest, the evidential (or likelihood) framework offers a methodological perspective that potentially bridges these two inferential paradigms. In this Concise Translational Review, we introduce readers to the evidential approach. To present the evidential approach as an analytical tool for critical care trials, we demonstrate its application

SUBMITTER: Zampieri FG 

PROVIDER: S-EPMC12432443 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature