Clarithromycin, ixazomib, pomalidomide, dexamethasone for relapsed/refractory myeloma: survival and correlative analysis.

ABSTRACT: Clarithromycin is a macrolide antibiotic with anti-multiple myeloma (MM) activity when combined with dexamethasone and immunomodulatory agents. This phase 1/2 study of clarithromycin, ixazomib, pomalidomide, and dexamethasone (ClIPd) assessed tolerability and efficacy in relapsed/refractory MM. The primary end points were the maximal tolerated and recommended phase 2 dose. Key secondary end points were the overall response rate (ORR) (≥partial response), disease control rate (DCR) (≥stable disease), progression-free survival (PFS), and overall survival (OS). All 4 medications were given at full dose for 6 cycles. Pomalidomide, ixazomib, and dexamethasone were given at reduced doses with full-dose clarithromycin in subsequent maintenance cycles until unacceptable toxicity or progression. Cl

SUBMITTER: Rosenberg AS 

PROVIDER: S-EPMC12432457 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature