Unveiling molecular mechanisms of strobilurin resistance in the cacao pathogen <i>Moniliophthora perniciosa</i>.

ABSTRACT: Strobilurin fungicides inhibit mitochondrial respiration, leading to ATP depletion and oxidative stress. Although widely used in agriculture, these chemicals are ineffective against the cacao pathogen Moniliophthora perniciosa. Here, we show that M. perniciosa tolerates high concentrations of the commercial strobilurin azoxystrobin in vitro. Transcriptomic analysis revealed that short-term exposure triggers upregulation of genes related to catabolic pathways, including the glyoxylate cycle and fatty acid degradation, alongside repression of genes involved in anabolic processes, such as cell division and ribosome biogenesis. Simultaneously, genes associated with cellular detoxification and oxidative stress responses were strongly induced. These alterations suggest that

SUBMITTER: Prado PFV 

PROVIDER: S-EPMC12432460 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature