Hazelnut: Explorations toward the Biocatalytic Synthesis of its Aroma Precursor.

ABSTRACT: Biocatalysis gains significant industrial interest due to its controlled stereoselectivity and use of mild process conditions. Here, a biosynthetic route is proposed for the synthesis of filbertone (5-methyl-2-hepten-4-one, 1), which is the principal flavor compound of hazelnut. The enantiomeric purity of the industrially synthesized compound is defined, contrary to the natural aroma, which varies according to the source of the nut, extraction conditions, and treatments. The novel synthetic pathway for a hazelnut aroma precursor proposed here consists of a multienzyme cascade, which starts from the two amino acids D-Ile and L-Thr that are individually converted by enzyme catalysts, i.e., D-amino acid oxidase and threonine deaminase, followed by CC ligation of the obtained products, allowi

SUBMITTER: Salvado-Pau M 

PROVIDER: S-EPMC12432537 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature