Comparative effectiveness of perioperative strategies for resectable gastric and gastroesophageal junction cancer: a Bayesian network meta-analysis.

ABSTRACT: Perioperative strategies for resectable gastric and gastroesophageal junction (GEJ) adenocarcinomas are continuously evolving, with recent regimens, particularly those incorporating immunotherapy, showing promising results, although their comparative efficacy remains uncertain. We conducted a Bayesian network meta-analysis of randomized controlled trials (RCTs) published between January 2004 and March 2025 that compared perioperative treatments involving chemotherapy, radiotherapy, immunotherapy, or targeted agents. Five outcomes were analyzed: overall survival (OS), progression-free survival (PFS), R0 resection, pathological complete response (pCR), and major pathological response (MPR). A Bayesian random-effects model was applied to estimate hazard ratios (HRs) and odds ratios (ORs), and

SUBMITTER: Chi L 

PROVIDER: S-EPMC12432556 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature