Effects of liposomal bupivacaine for erector spinae plane block on perioperative immune function and analgesia in thoracoscopic lung cancer surgery.

ABSTRACT:

Objective

To assess the immunomodulatory and analgesic effects of liposomal bupivacaine compared to ropivacaine on erector spinae plane block (ESPB) for patients undergoing thoracoscopic lung cancer surgery.

Methods

This retrospective study included 260 patients undergoing thoracoscopic lung cancer surgery. Patients were divided into two groups based on anesthesia methods: the liposomal bupivacaine group (n = 134) and the ropivacaine group (n = 126). Both groups received general anesthesia followed by ESPB. Perioperative inflammatory markers (IL-6, TNF-α, CRP), immunoglobulins (IgA, IgG, IgM), and analgesic outcomes (Numerical Rating Scale (NRS) scores) were measured at various postoperative time points. Cellular inflammatory markers, including white blood cell (WBC) counts

SUBMITTER: Wang C 

PROVIDER: S-EPMC12432565 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature