Emerging exosomal biomarkers for essential hypertension: a systematic review.

ABSTRACT:

Background

Exosomes show promise as biomarkers for essential hypertension (EH) progression and complications. However, existing studies on dysregulation of exosomal biomarkers in hypertension lack consistency. Thus, we conducted a comprehensive systematic review to synthesize evidence on exosomal biomarkers associated with EH.

Methods

We performed an exhaustive search across PubMed, Embase, Web of Science, the Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, and Chinese Clinical Trial Registry. Our search encompassed all available Chinese and English records from their inception through August 14^th, 2025, without any restrictions on study design. The primary outcome focused on exosomal microRNA (miRNA) alterations, with secondary analys

SUBMITTER: Zhong D 

PROVIDER: S-EPMC12432595 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature