Identification of disulfidptosis-related long non-coding RNA signature to predict the prognosis, immunotherapy, and chemotherapy options in acute myeloid leukemia.

ABSTRACT:

Background

Disulfidptosis, a recently identified programmed cell death mechanism, has emerged as a critical regulator in tumorigenesis and demonstrates significant prognostic value across multiple cancer types. However, the prognostic significance of disulfidptosis-related long non-coding RNAs (DRLs) in acute myeloid leukemia (AML) and their functional implications in the tumor immune microenvironment (TIME) remain poorly characterized. Furthermore, the expression patterns and regulatory mechanisms of DRLs in AML require systematic investigation to elucidate their potential clinical applications. The study aims to investigate the prognostic and immunotherapeutic implications of DRLs in AML.

Methods

RNA sequencing and clinical data for AML samples, as well as genotype-tissue

SUBMITTER: Huang M 

PROVIDER: S-EPMC12432606 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature