Beyond the tumor: towards a cachexia-based host phenotype through body composition analysis in patients with resectable lung cancer.

ABSTRACT: Cancer cachexia, characterized by involuntary weight loss and extensive muscle and adipose tissue wasting, is a major contributor to morbidity and mortality in cancer patients. To date, no effective medical intervention can completely reverse this multifactorial syndrome, which is driven by different metabolic changes. Identification of cachectic patients is primarily based on alterations in body composition and the assessment of systemic metabolic and inflammatory changes. While these changes have been thoroughly described in patients with more advanced stages of lung cancer, their role in resectable lung cancer remains less explored. In this review, we summarize the different methods to assess body composition metrics such as skeletal muscle (SM) mass, fat distribution and overall body c

SUBMITTER: Verkoulen KCHA 

PROVIDER: S-EPMC12432608 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature