Biomarkers of increased bleeding risk in patients with atrial fibrillation on oral anticoagulation: a narrative review.

ABSTRACT:

Background and objective

Atrial fibrillation (AF) is an independent risk factor for ischemic stroke and systemic thromboembolism. Oral anticoagulation (OAC) effectively reduces stroke risk but also increases bleeding risk. Current clinical risk scores for bleeding in AF patients have only modest predictive ability and overlapping stroke and bleeding risk factors complicate treatment decisions. This narrative review aims to review and evaluate current evidence on biomarkers that can predict bleeding risk in AF patients on OAC and assess their integration into risk-scoring systems to guide more personalised clinical decision-making.

Methods

This narrative review summarises data from major clinical trials and cohort studies evaluating bleeding-related biomarkers in AF patients

SUBMITTER: Ibrahem A 

PROVIDER: S-EPMC12432616 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature