Nontuberculous Mycobacterial Disease in Solid-Organ Transplant Recipients and the General Population.

ABSTRACT:

Importance

Single-center studies suggest that solid-organ transplant recipients (SOTRs) with nontuberculous mycobacterial disease (NTM-D) face increased mortality, particularly in the presence of comorbidities such as chronic lung disease. Large-scale studies are needed to quantify the risk of NTM-D and its impact on mortality in this population.

Objective

To compare the risk of NTM-D between the general population and SOTRs, stratified by lung and nonlung transplants, and to assess whether NTM-D is associated with increased mortality risk in SOTRs.

Design, setting, and participants

This population-based cohort study was conducted in Ontario, Canada, from April 1, 2002, to December 31, 2018. Adult SOTRs were matched 1:10 with general population controls by age, sex, a

SUBMITTER: Hosseini-Moghaddam SM 

PROVIDER: S-EPMC12432629 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature