Short-course hypofractionated radiotherapy of 4 Gy per fraction for limited-stage small cell lung cancer: a randomized pilot trial.

ABSTRACT:

Background

Local-regional relapse remains high after the standard radiotherapy regimen for limited-stage small cell lung cancer (LS-SCLC). Short-course hypofractionated radiotherapy may improve disease control. In this single-institution open-label pilot trial, we aimed to explore the preliminary safety and efficacy of short-course hypofractionated radiotherapy with 4 Gy per fraction.

Methods

LS-SCLC patients (18 to 75 years old) with Karnofsky performance scale score (KPS) over 70 were enrolled. Patients were randomized with a ratio of 1:1 to receive radiotherapy of 48 Gy/12 f once daily (low-dose arm) or 60 Gy/15 f once daily (high-dose arm). Concurrent chemotherapy was administered for 4 to 6 cycles. The primary objective was the radiation-induced toxicity and the seconda

SUBMITTER: Li XY 

PROVIDER: S-EPMC12432646 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature