Effect of type 2 diabetes mellitus on systemic treatment for advanced non-small cell lung cancer.

ABSTRACT:

Background

The effect of type 2 diabetes mellitus (T2DM) on treatments for advanced non-small cell lung cancer (NSCLC) remains unelucidated. We aimed to assess the effect of T2DM on the treatment for advanced NSCLC.

Methods

We retrospectively investigated clinicopathological character, treatment effect, and adverse events (AEs) in advanced NSCLC patients started on systemic treatment at Nippon Medical School Chiba-Hokusoh Hospital from 2018 to 2024.

Results

The numbers of T2DM and non-T2DM patients among those undergoing immune checkpoint inhibitor (ICI) therapy, molecular targeted therapy (MTT), and cytotoxic chemotherapy (CTT) were 37 and 78, 30 and 86, 9 and 17, respectively. The overall survival (OS) of patients complicated T2DM was significantly worse in total (1

SUBMITTER: Kato Y 

PROVIDER: S-EPMC12432656 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature