Shared genetics of lung cancer and type 2 diabetes: a large-scale genome-wide cross-trait analysis.

ABSTRACT:

Background

Lung cancer (LCA) and type 2 diabetes (T2D) are major global health burdens, with accumulating evidence suggesting a genomic link. This study systematically investigates the shared genetic architecture between LCA subtypes [small cell lung cancer (SCLC), lung squamous cell carcinoma (LUSC), lung adenocarcinoma (LUAD)] and T2D using large-scale genome-wide association studies (GWAS).

Methods

We conducted genome-wide genetic correlation analyses using linkage disequilibrium score regression (LDSC) and local genetic correlation analyses via heritability estimation from summary statistics (HESS). Pleiotropic variants were identified using the pleiotropic analysis under composite null hypothesis (PLACO), and functional annotation was performed with functional mapping a

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12432657 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature