Intense light as potential future therapy for myocardial injury in patients after non cardiac surgery: lessons from mice and men.

ABSTRACT:

Background

Studies on light-elicited endothelial period circadian regulator 2 (PER2) mediated cardioprotection revealed a critical role of PER2/hypoxia inducible factor 1 alpha (HIF1A) regulated endothelial factor ANGPTL4 for endothelial barrier protection during myocardial ischemia and reperfusion injury (IRI). Based on these observations, we deepened our studies on light-elicited cardioprotective mechanisms.

Methods

All animal and human studies had Institutional Animal Care and Use Committee (IACUC) and Colorado Multiple Institutional Review Board (COMIRB) approval. To study myocardial IRI, an in-situ mouse model for myocardial IRI was used. To study light-elicited mechanisms during myocardial IRI, endothelial-specific Per2-deficient mice were treated with the PER2

SUBMITTER: Bertazzo J 

PROVIDER: S-EPMC12432674 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature