Thyroid differentiation score-related genes and prognostic model for thyroid cancer.

ABSTRACT:

Background

Thyroid differentiation score (TDS) reflects the differentiation degree of thyroid cancer (THCA). This study aimed to construct a TDS-related prognostic risk model for THCA and explore the potential biomarkers.

Methods

Using The Cancer Genome Atlas (TCGA)-THCA dataset, overlapping differentially expressed genes (DEGs) between THCA-DEGs and TDS-DEGs were identified for functional enrichment analyses to determine their biological functions. Least absolute shrinkage and selection operator (Lasso) and Cox regression analyses were applied to construct a prognostic model. The model's predictive performance was validated through Kaplan-Meier curves, receiver operating characteristic curves, and decision curve analyses. Gene set enrichment analysis (GSEA) was performed to

SUBMITTER: Lin S 

PROVIDER: S-EPMC12432675 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature